The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

BACKGROUND: Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been descri...

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Detalles Bibliográficos
Autores principales: Mátyás, Csaba, Németh, Balázs Tamás, Oláh, Attila, Hidi, László, Birtalan, Ede, Kellermayer, Dalma, Ruppert, Mihály, Korkmaz-Icöz, Sevil, Kökény, Gábor, Horváth, Eszter Mária, Szabó, Gábor, Merkely, Béla, Radovits, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628236/
https://www.ncbi.nlm.nih.gov/pubmed/26520063
http://dx.doi.org/10.1186/s12933-015-0309-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628236/
https://www.ncbi.nlm.nih.gov/pubmed/26520063
http://dx.doi.org/10.1186/s12933-015-0309-x

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