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Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents
Chronic hepatitis C virus (HCV) infection has become a major public health burden worldwide. Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro. The structure-activity analysis revealed that (i) sophocarpinic acids with a D-sec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629077/ https://www.ncbi.nlm.nih.gov/pubmed/26579400 http://dx.doi.org/10.1016/j.apsb.2014.06.002 |