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Characterization of impurities in cefpodoxime proxetil using LC–MS(n)

Reversed-phase liquid chromatography coupled with electrospray ionization tandem mass spectrometry (ESI-MS/MS) was used to characterize impurities in cefpodoxime proxetil, an ester-modified prodrug. Based on the mechanisms by which cephalosporins are degraded, stress tests were designed and performe...

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Detalles Bibliográficos
Autores principales: Li, Jin, Zhang, Dousheng, Hu, Changqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629086/
https://www.ncbi.nlm.nih.gov/pubmed/26579402
http://dx.doi.org/10.1016/j.apsb.2014.06.007