Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression

RNA interference (RNAi) is useful for selective gene silencing. Cytochrome P450 3A4 (CYP3A4), which metabolizes approximately 50% of drugs in clinical use, plays an important role in drug metabolism. In this study, we aimed to develop a short hairpin RNA (shRNA) to modulate CYP3A4 expression. Three...

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Detalles Bibliográficos
Autores principales: Xu, Siyun, Xiao, Yongsheng, Li, Li, Yu, Lushan, Jiang, Huidi, Yu, Aiming, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629097/
https://www.ncbi.nlm.nih.gov/pubmed/26579404
http://dx.doi.org/10.1016/j.apsb.2014.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629097/
https://www.ncbi.nlm.nih.gov/pubmed/26579404
http://dx.doi.org/10.1016/j.apsb.2014.08.003

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