Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Although they differ in structure by a single methyl group, the inhibitory effect of G1 (IC(50)=26...

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Detalles Bibliográficos
Autores principales: Fang, Jiansong, Wu, Ping, Yang, Ranyao, Gao, Li, Li, Chao, Wang, Dongmei, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629110/
https://www.ncbi.nlm.nih.gov/pubmed/26579414
http://dx.doi.org/10.1016/j.apsb.2014.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629110/
https://www.ncbi.nlm.nih.gov/pubmed/26579414
http://dx.doi.org/10.1016/j.apsb.2014.10.002

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