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Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

Inflammatory signal-mediated release of high-mobility group box 1 (HMGB1) is a damage-associated molecular pattern or alarmin. The inflammatory functions of HMGB1 have been extensively investigated; however, less is known about the mechanisms controlling HMGB1 release. We show that SIRT1, the human...

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Detalles Bibliográficos
Autores principales:	Hwang, Jung Seok, Choi, Hyuk Soo, Ham, Sun Ah, Yoo, Taesik, Lee, Won Jin, Paek, Kyung Shin, Seo, Han Geuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629154/ https://www.ncbi.nlm.nih.gov/pubmed/26522327 http://dx.doi.org/10.1038/srep15971

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