Design, synthesis and evaluation of genistein-polyamine conjugates as multi-functional anti-Alzheimer agents

A series of genistein-polyamine conjugates (4a–4h) were designed, synthesized and evaluated as multi-functional anti-Alzheimer agents. The results showed that these compounds had significant cholinesterases (ChEs) inhibitory activity. Compound 4b exhibited the strongest inhibition to acetylcholinest...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Wang, Jiang, Hong, Chen, Luo, Wen, Wang, Chaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629212/
https://www.ncbi.nlm.nih.gov/pubmed/26579427
http://dx.doi.org/10.1016/j.apsb.2014.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629212/
https://www.ncbi.nlm.nih.gov/pubmed/26579427
http://dx.doi.org/10.1016/j.apsb.2014.12.008

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