A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Gowen, Benjamin G, Chim, Bryan, Marceau, Caleb D, Greene, Trever T, Burr, Patrick, Gonzalez, Jeanmarie R, Hesser, Charles R, Dietzen, Peter A, Russell, Teal, Iannello, Alexandre, Coscoy, Laurent, Sentman, Charles L, Carette, Jan E, Muljo, Stefan A, Raulet, David H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629278/
https://www.ncbi.nlm.nih.gov/pubmed/26565589
http://dx.doi.org/10.7554/eLife.08474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629278/
https://www.ncbi.nlm.nih.gov/pubmed/26565589
http://dx.doi.org/10.7554/eLife.08474

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