Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca(2+) influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular protons trigger a novel form of neuronal ne...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Zhi, Wang, Jing-Jing, Huang, Yu, Liu, Fan, Zeng, Wei-Zheng, Li, Ying, Xiong, Zhi-Gang, Zhu, Michael X, Xu, Tian-Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629285/
https://www.ncbi.nlm.nih.gov/pubmed/26523449
http://dx.doi.org/10.7554/eLife.05682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629285/
https://www.ncbi.nlm.nih.gov/pubmed/26523449
http://dx.doi.org/10.7554/eLife.05682

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