Proteome-wide small molecule and metabolite interaction mapping

Thermal stabilization of proteins upon ligand binding provides an efficient means to assess binding of small molecules to proteins. We show here that in combination with quantitative mass spectrometry the approach allows for the systematic survey of protein engagement by cellular metabolites and dru...

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Detalles Bibliográficos
Autores principales: Huber, Kilian V. M., Olek, Karin M., Müller, André C., Soon Heng Tan, Chris, Bennett, Keiryn L., Colinge, Jacques, Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629415/
https://www.ncbi.nlm.nih.gov/pubmed/26389571
http://dx.doi.org/10.1038/nmeth.3590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629415/
https://www.ncbi.nlm.nih.gov/pubmed/26389571
http://dx.doi.org/10.1038/nmeth.3590

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