Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study

(E)-Methyl-4-aryl-4-oxabut-2-enoate (YH-8) is a novel PKnB protein kinase inhibitor with good anti-tuberculosis activity. To evaluate its pharmacokinetics in rats, a sensitive and selective high performance liquid chromatography–tandem mass spectrometric (LC--MS/MS) method has been developed and val...

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Detalles Bibliográficos
Autores principales: Zhai, Qianqian, Pang, Jing, Li, Guoqing, Li, Congran, Yang, Xinyi, Yu, Liyan, Wang, Yucheng, Li, Jian, You, Xuefu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629422/
https://www.ncbi.nlm.nih.gov/pubmed/26579477
http://dx.doi.org/10.1016/j.apsb.2015.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629422/
https://www.ncbi.nlm.nih.gov/pubmed/26579477
http://dx.doi.org/10.1016/j.apsb.2015.04.001

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