Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography

Nucleotidyl-transfer reaction catalyzed by DNA polymerase is a fundamental enzymatic reaction for DNA synthesis. Until now, a number of structural and kinetic studies on DNA polymerases have proposed a two-metalion mechanism of the nucleotidyl-transfer reaction. However, the actual reaction process...

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Detalles Bibliográficos
Autores principales: Nakamura, Teruya, Zhao, Ye, Yamagata, Yuriko, Hua, Yue-jin, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629682/
https://www.ncbi.nlm.nih.gov/pubmed/27493538
http://dx.doi.org/10.2142/biophysics.9.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629682/
https://www.ncbi.nlm.nih.gov/pubmed/27493538
http://dx.doi.org/10.2142/biophysics.9.31

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