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Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography

Nucleotidyl-transfer reaction catalyzed by DNA polymerase is a fundamental enzymatic reaction for DNA synthesis. Until now, a number of structural and kinetic studies on DNA polymerases have proposed a two-metalion mechanism of the nucleotidyl-transfer reaction. However, the actual reaction process...

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Detalles Bibliográficos
Autores principales:	Nakamura, Teruya, Zhao, Ye, Yamagata, Yuriko, Hua, Yue-jin, Yang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2013
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629682/ https://www.ncbi.nlm.nih.gov/pubmed/27493538 http://dx.doi.org/10.2142/biophysics.9.31

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