Charge-Based Inhibitors of Amylin Fibrillization and Toxicity

To test the hypothesis that electrostatic repulsion is an important force opposing amyloid fibril assembly, we designed peptides that substitute strings of positively or negatively charged residues into the sequence of the amyloidogenic hormone amylin, which contributes to type 2 diabetes pathology....

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Detalles Bibliográficos
Autores principales: Patil, Sharadrao M., Alexandrescu, Andrei T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630399/
https://www.ncbi.nlm.nih.gov/pubmed/26576438
http://dx.doi.org/10.1155/2015/946037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630399/
https://www.ncbi.nlm.nih.gov/pubmed/26576438
http://dx.doi.org/10.1155/2015/946037

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