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EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance

BACKGROUND: Enhanced signalling via the epidermal growth factor receptor (EGFR) is a hallmark of multiple human carcinomas. However, in recent years data have accumulated that EGFR might also be hyperactivated in human sarcomas. Aim of this study was to investigate the influence of EGFR inhibition o...

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Detalles Bibliográficos
Autores principales: Sevelda, Florian, Mayr, Lisa, Kubista, Bernd, Lötsch, Daniela, van Schoonhoven, Sushilla, Windhager, Reinhard, Pirker, Christine, Micksche, Michael, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630894/
https://www.ncbi.nlm.nih.gov/pubmed/26526352
http://dx.doi.org/10.1186/s13046-015-0251-5