Cargando…

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

BACKGROUND: Reactive microglia are commonly seen in retinal degenerative diseases, and neurotoxic microglia responses can contribute to photoreceptor cell death. We and others have previously shown that translocator protein (18 kDa) (TSPO) is highly induced in retinal degenerations and that the sele...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scholz, Rebecca, Caramoy, Albert, Bhuckory, Mohajeet B., Rashid, Khalid, Chen, Mei, Xu, Heping, Grimm, Christian, Langmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630900/ https://www.ncbi.nlm.nih.gov/pubmed/26527153 http://dx.doi.org/10.1186/s12974-015-0422-5

Ejemplares similares

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
por: Karlstetter, Marcus, et al.
Publicado: (2014)

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration
por: Scholz, Rebecca, et al.
Publicado: (2015)

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia
por: Loth, Meredith K., et al.
Publicado: (2020)

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain
por: Nutma, Erik, et al.
Publicado: (2021)

18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
por: Tournier, Benjamin B., et al.
Publicado: (2023)

Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
por: Lee, Ji-Won, et al.
Publicado: (2016)

The 18 kDa Translocator Protein, Microglia and Neuroinflammation
por: Liu, Guo‐Jun, et al.
Publicado: (2014)

Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells
por: Bader, Stefanie, et al.
Publicado: (2023)

Translocator Protein 18 kDa (TSPO) Is Regulated in White and Brown Adipose Tissue by Obesity
por: Thompson, Misty M., et al.
Publicado: (2013)

Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
por: Liu, Jie, et al.
Publicado: (2022)

Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells
por: Manku, Gurpreet, et al.
Publicado: (2016)

Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function
por: Yao, Rumeng, et al.
Publicado: (2020)

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
por: Schollhammer, Romain, et al.
Publicado: (2021)

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
por: Tabel, Mona, et al.
Publicado: (2022)

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)()
por: Colasanti, Alessandro, et al.
Publicado: (2013)

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
por: Gui, Yaxing, et al.
Publicado: (2019)

Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells
por: González-Blanco, Laura, et al.
Publicado: (2021)

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
por: Owen, David R, et al.
Publicado: (2012)

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration
por: Wu, Xiaoting, et al.
Publicado: (2013)

Translocator protein 18 kDa (TSPO): old dogma, new mice, new structure, and new questions for neuroprotection
por: Kim, Eun-Jung, et al.
Publicado: (2015)

IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration
por: Behnke, Verena, et al.
Publicado: (2020)

De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein
por: Germelli, Lorenzo, et al.
Publicado: (2021)

Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
por: Ching, Alex Sik Chung, et al.
Publicado: (2011)

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases
por: Dupont, Anne-Claire, et al.
Publicado: (2017)

Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
por: Weidner, Lorraine, et al.
Publicado: (2023)

In vivo evaluation of a novel (18)F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain
por: Yan, Xuefeng, et al.
Publicado: (2023)

The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects
por: Tournier, Benjamin B., et al.
Publicado: (2022)

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration
por: Khan, Amir Saeed, et al.
Publicado: (2020)

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans
por: Owen, David R, et al.
Publicado: (2017)

Microglia in Retinal Degeneration
por: Rashid, Khalid, et al.
Publicado: (2019)

Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice
por: Wang, Wei, et al.
Publicado: (2016)

T193. CHRONIC HALOPERIDOL TREATMENT INDUCES SIGNIFICANT CHANGES IN MICROGLIA AND IN THE EXPRESSION OF THE 18 KDA TRANSLOCATOR PROTEIN TSPO IN NAIVE ADULT RAT BRAINS
por: Cotel, Marie, et al.
Publicado: (2018)

[(125) I]IodoDPA-713 Binding to 18 kDa Translocator Protein (TSPO) in a Mouse Model of Intracerebral Hemorrhage: Implications for Neuroimaging
por: Bonsack, Frederick, et al.
Publicado: (2018)

Imaging adipose tissue browning using the TSPO-18kDa tracer [(18)F]FEPPA
por: Hartimath, S.V., et al.
Publicado: (2019)

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
por: Pradhan, Arpit Kumar, et al.
Publicado: (2023)

Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations
por: Rashid, Khalid, et al.
Publicado: (2018)

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
por: Zhang, Xiao-Ying, et al.
Publicado: (2018)

Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism rs6971
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2014)

PS30. Gender difference in stress responses as examined by TSPO (Translocator Protein 18 kDa), cortisol and STAI (State-Trait Anxiety Inventory) in normal human subjects.
por: Nakamoto, Yurie, et al.
Publicado: (2016)

Preclinical evaluation of (S)-[(18)F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971
por: Ramakrishnan, Nisha K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eu12hra40aq6ktvua2rmkln1i4