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Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes
BACKGROUND: Streptomyces, as the main source of antibiotics, has been intensively exploited for discovering new drug candidates to combat the evolving pathogens. Disruption of wblA, an actinobacteria-specific gene controlling major developmental transition, can cause the alteration of phenotype and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630966/ https://www.ncbi.nlm.nih.gov/pubmed/26525981 http://dx.doi.org/10.1186/s12934-015-0359-5 |