Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology

We demonstrate proof-of-concept for the use of massively multiplexed PCR and next-generation sequencing (mmPCR-NGS) to identify both clonal and subclonal copy-number variants (CNVs) in circulating tumor DNA. This is the first report of a targeted methodology for detection of CNVs in plasma. Using an...

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Detalles Bibliográficos
Autores principales: Kirkizlar, Eser, Zimmermann, Bernhard, Constantin, Tudor, Swenerton, Ryan, Hoang, Bin, Wayham, Nicholas, Babiarz, Joshua E., Demko, Zachary, Pelham, Robert J., Kareht, Stephanie, Simon, Alexander L., Jinnett, Kristine N., Rabinowitz, Matthew, Sigurjonsson, Styrmir, Hill, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631096/
https://www.ncbi.nlm.nih.gov/pubmed/26500031
http://dx.doi.org/10.1016/j.tranon.2015.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631096/
https://www.ncbi.nlm.nih.gov/pubmed/26500031
http://dx.doi.org/10.1016/j.tranon.2015.08.004

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