Using Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins

Gene duplication enables the functional diversification in species. It is thought that duplicated genes may be able to compensate if the function of one of the gene copies is disrupted. This possibility is extensively debated with some studies reporting proteome-wide compensation, whereas others sug...

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Detalles Bibliográficos
Autores principales: Miura, Sayaka, Tate, Stephanie, Kumar, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631161/
https://www.ncbi.nlm.nih.gov/pubmed/26604664
http://dx.doi.org/10.4137/EBO.S30594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631161/
https://www.ncbi.nlm.nih.gov/pubmed/26604664
http://dx.doi.org/10.4137/EBO.S30594

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