Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds

Since deleterious mutations may be rescued by secondary mutations during evolution, compensatory evolution could identify genetic solutions leading to therapeutic targets. Here, we tested this hypothesis and examined whether these solutions would be universal or would need to be adapted to one'...

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Detalles Bibliográficos
Autores principales: Filteau, Marie, Hamel, Véronique, Pouliot, Marie-Christine, Gagnon-Arsenault, Isabelle, Dubé, Alexandre K, Landry, Christian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631203/
https://www.ncbi.nlm.nih.gov/pubmed/26459777
http://dx.doi.org/10.15252/msb.20156444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631203/
https://www.ncbi.nlm.nih.gov/pubmed/26459777
http://dx.doi.org/10.15252/msb.20156444

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