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Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds
Since deleterious mutations may be rescued by secondary mutations during evolution, compensatory evolution could identify genetic solutions leading to therapeutic targets. Here, we tested this hypothesis and examined whether these solutions would be universal or would need to be adapted to one'...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631203/ https://www.ncbi.nlm.nih.gov/pubmed/26459777 http://dx.doi.org/10.15252/msb.20156444 |