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Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes

The genetic targeting of mouse models has given insight into complex processes. However, phenotypes of genetically targeted mice are susceptible to artifacts due to gene manipulation, which may lead to misinterpretation of the observations. To directly address these issues, we have compared the immu...

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Detalles Bibliográficos
Autores principales: Sareila, Outi, Hagert, Cecilia, Rantakari, Pia, Poutanen, Matti, Holmdahl, Rikard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631371/
https://www.ncbi.nlm.nih.gov/pubmed/26528554
http://dx.doi.org/10.1371/journal.pone.0141974