Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft

Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) is a critical enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis. cPEPCK converts oxaloacetic acid (OAA) into phosphoenol pyruvate (PEP) in the presence of GTP. cPEPCK is known to be associated with type 2 diabetes. Genistein i...

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Detalles Bibliográficos
Autores principales: Katiyar, Shashank Prakash, Jain, Arpit, Dhanjal, Jaspreet Kaur, Sundar, Durai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631375/
https://www.ncbi.nlm.nih.gov/pubmed/26528723
http://dx.doi.org/10.1371/journal.pone.0141987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631375/
https://www.ncbi.nlm.nih.gov/pubmed/26528723
http://dx.doi.org/10.1371/journal.pone.0141987

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