FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

There is great interest in increasing proteins’ stability to enhance their utility as biocatalysts, therapeutics, diagnostics and nanomaterials. Directed evolution is a powerful, but experimentally strenuous approach. Computational methods offer attractive alternatives. However, due to the limited r...

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Detalles Bibliográficos
Autores principales: Bednar, David, Beerens, Koen, Sebestova, Eva, Bendl, Jaroslav, Khare, Sagar, Chaloupkova, Radka, Prokop, Zbynek, Brezovsky, Jan, Baker, David, Damborsky, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631455/
https://www.ncbi.nlm.nih.gov/pubmed/26529612
http://dx.doi.org/10.1371/journal.pcbi.1004556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631455/
https://www.ncbi.nlm.nih.gov/pubmed/26529612
http://dx.doi.org/10.1371/journal.pcbi.1004556

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