Cargando…
FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants
There is great interest in increasing proteins’ stability to enhance their utility as biocatalysts, therapeutics, diagnostics and nanomaterials. Directed evolution is a powerful, but experimentally strenuous approach. Computational methods offer attractive alternatives. However, due to the limited r...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631455/ https://www.ncbi.nlm.nih.gov/pubmed/26529612 http://dx.doi.org/10.1371/journal.pcbi.1004556 |