Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase

Hepatitis B virus polymerase (HBV Pol) is an important target for anti-HBV drug development; however, its low solubility and stability in vitro has hindered detailed structural studies. Certain nucleotide reverse transcriptase (RT) inhibitors (NRTIs) such as tenofovir and lamivudine can inhibit both...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakamura, Akiyoshi, Tamura, Noriko, Yasutake, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631587/
https://www.ncbi.nlm.nih.gov/pubmed/26527265
http://dx.doi.org/10.1107/S2053230X15017896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631587/
https://www.ncbi.nlm.nih.gov/pubmed/26527265
http://dx.doi.org/10.1107/S2053230X15017896

Ejemplares similares