Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing

Flaviviruses sample an ensemble of virion conformations resulting from the conformational flexibility of their structural proteins. To investigate how sequence variation among strains impacts virus breathing, we performed studies with the monoclonal antibody (MAb) E111, which binds an inaccessible d...

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Detalles Bibliográficos
Autores principales: Dowd, Kimberly A., DeMaso, Christina R., Pierson, Theodore C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631804/
https://www.ncbi.nlm.nih.gov/pubmed/26530385
http://dx.doi.org/10.1128/mBio.01559-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631804/
https://www.ncbi.nlm.nih.gov/pubmed/26530385
http://dx.doi.org/10.1128/mBio.01559-15

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