IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance

Polymorphisms near the interferon lambda 3 (IFNL3) gene strongly predict clearance of hepatitis C virus (HCV) infection. We analyzed a variant (rs4803217 G/T) located within the IFNL3 mRNA 3′ untranslated region (UTR); the G allele (protective allele) is associated with elevated therapeutic HCV clea...

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Detalles Bibliográficos
Autores principales: Lu, Yi-Fan, Mauger, David M., Goldstein, David B., Urban, Thomas J., Weeks, Kevin M., Bradrick, Shelton S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631997/
https://www.ncbi.nlm.nih.gov/pubmed/26531896
http://dx.doi.org/10.1038/srep16037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631997/
https://www.ncbi.nlm.nih.gov/pubmed/26531896
http://dx.doi.org/10.1038/srep16037

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