Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B

Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by c...

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Detalles Bibliográficos
Autores principales: Mukai, Satomi, Yabuta, Norikazu, Yoshida, Kaori, Okamoto, Ayumi, Miura, Daisaku, Furuta, Yasuhide, Abe, Takaya, Nojima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632022/
https://www.ncbi.nlm.nih.gov/pubmed/26530630
http://dx.doi.org/10.1038/srep16173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632022/
https://www.ncbi.nlm.nih.gov/pubmed/26530630
http://dx.doi.org/10.1038/srep16173

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