Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome

Chromosome 22q11.2 microdeletions impart a high but incomplete risk for schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 haploinsufficiency. In a proof-of-principle study to assess the power of this model, we used high-quality, whole-genome sequencing of nine individuals with...

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Detalles Bibliográficos
Autores principales: Merico, Daniele, Zarrei, Mehdi, Costain, Gregory, Ogura, Lucas, Alipanahi, Babak, Gazzellone, Matthew J., Butcher, Nancy J., Thiruvahindrapuram, Bhooma, Nalpathamkalam, Thomas, Chow, Eva W. C., Andrade, Danielle M., Frey, Brendan J., Marshall, Christian R., Scherer, Stephen W., Bassett, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2015
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632064/
https://www.ncbi.nlm.nih.gov/pubmed/26384369
http://dx.doi.org/10.1534/g3.115.021345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632064/
https://www.ncbi.nlm.nih.gov/pubmed/26384369
http://dx.doi.org/10.1534/g3.115.021345

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