Cargando…

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a novel class of natural products including several antibiotics and bacterial toxins. In countless RiPP biosynthetic pathways, cobalamin-dependent radical SAM (B(12)/rSAM) enzymes play a pivotal role. In the biosynthetic...

Descripción completa

Detalles Bibliográficos
Autores principales: Benjdia, Alhosna, Pierre, Stéphane, Gherasim, Carmen, Guillot, Alain, Carmona, Manon, Amara, Patricia, Banerjee, Ruma, Berteau, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632189/
https://www.ncbi.nlm.nih.gov/pubmed/26456915
http://dx.doi.org/10.1038/ncomms9377