Cargando…

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome

Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer. Here, we investigated the pathogenic impact and prognostic significance of WRAP53β in connection with epithelial ovarian canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hedström, E, Pederiva, C, Farnebo, J, Nodin, B, Jirström, K, Brennan, D J, Farnebo, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632285/ https://www.ncbi.nlm.nih.gov/pubmed/26426684 http://dx.doi.org/10.1038/cddis.2015.250

Ejemplares similares

WRAP53 promotes cancer cell survival and is a potential target for cancer therapy
por: Mahmoudi, S, et al.
Publicado: (2011)

On the road with WRAP53β: guardian of Cajal bodies and genome integrity
por: Henriksson, Sofia, et al.
Publicado: (2015)

Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks
por: Rassoolzadeh, H, et al.
Publicado: (2016)

The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
por: Henriksson, Sofia, et al.
Publicado: (2014)

The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination
por: Bergstrand, Sofie, et al.
Publicado: (2019)

Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
por: Coucoravas, Christos, et al.
Publicado: (2016)

RNF8 - The Achilles heel of DNA repair when splicing rules
por: Pederiva, Chiara, et al.
Publicado: (2018)

The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
por: Silwal-Pandit, Laxmi, et al.
Publicado: (2015)

WRAP53β, survivin and p16(INK4a) expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer
por: Tiefenböck-Hansson, Katharina, et al.
Publicado: (2017)

The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1
por: Rassoolzadeh, Hanif, et al.
Publicado: (2016)

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
por: Mahmoudi, Salah, et al.
Publicado: (2010)

Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer
por: Nodin, Björn, et al.
Publicado: (2012)

Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal–Hreidarsson syndrome
por: Bergstrand, Sofie, et al.
Publicado: (2020)

Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
por: Mahmoudi, Salah, et al.
Publicado: (2018)

Splicing controls the ubiquitin response during DNA double-strand break repair
por: Pederiva, C, et al.
Publicado: (2016)

Expression of the global regulator SATB1 is an independent factor of poor prognosis in high grade epithelial ovarian cancer
por: Nodin, Björn, et al.
Publicado: (2012)

Evaluation of dyskerin expression and the Cajal body protein WRAP53β as potential prognostic markers for patients with primary vaginal carcinoma
por: Ranhem, Cecilia, et al.
Publicado: (2022)

Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long‐term follow‐up of the SweBCG91RT randomized trial
por: Egelberg, Moa, et al.
Publicado: (2023)

Association of common WRAP 53 variant with ovarian cancer risk in the Polish population
por: Mędrek, Krzysztof, et al.
Publicado: (2012)

Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer
por: Nodin, Björn, et al.
Publicado: (2013)

Prognostic impact of tumour-associated B cells and plasma cells in epithelial ovarian cancer
por: Lundgren, Sebastian, et al.
Publicado: (2016)

Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer
por: Berntsson, Jonna, et al.
Publicado: (2014)

Poor reliability and reproducibility of 3 different radio-graphical classification systems for distal ulna fractures
por: MOLONEY, Maria, et al.
Publicado: (2022)

Promoter methylation of Wrap53α, an antisense transcript of p53, is associated with the poor prognosis of patients with non-small cell lung cancer
por: Kim, Dong Sun, et al.
Publicado: (2018)

Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.
por: Welinder, Charlotte, et al.
Publicado: (2016)

Midface Osteotomies for Feminization of the Facial Skeleton
por: Lundgren, T. Kalle, et al.
Publicado: (2017)

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer
por: Larsson, Anna, et al.
Publicado: (2012)

Diaphyseal and Metaphyseal Modeling Defects—Clinical Findings and Identification of WRAP53 Deficiency in Craniometadiaphyseal Dysplasia
por: Hao, Yun, et al.
Publicado: (2021)

Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability
por: Brändstedt, Jenny, et al.
Publicado: (2014)

Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
por: Ehlén, Åsa, et al.
Publicado: (2010)

A Nordic survey of the management of palliative care in patients with head and neck cancer
por: Boëthius, Helena, et al.
Publicado: (2020)

Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer
por: Pouladi, Nasser, et al.
Publicado: (2019)

Incidence of distal ulna fractures in a Swedish county: 74/100,000 person-years, most of them treated non-operatively
por: Moloney, Maria, et al.
Publicado: (2019)

Distal ulna fractures in adults—subcapitular, transverse fractures did not benefit from surgical treatment
por: Moloney, Maria, et al.
Publicado: (2022)

Control of protein synthesis through mRNA pseudouridylation by dyskerin
por: Pederiva, Chiara, et al.
Publicado: (2023)

Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study
por: Jonsson, Liv, et al.
Publicado: (2011)

Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients
por: Gaber, Alexander, et al.
Publicado: (2010)

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
por: Talani, Charbél, et al.
Publicado: (2019)

The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset
por: Gadelha, Renan Brito, et al.
Publicado: (2022)

Oncogenic Activity of Wrap53 in Human Colorectal Cancer In Vitro and in Nude Mouse Xenografts
por: Zhu, Yu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_f4ruh6qr0a4nn5binvurmgss1u