Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5

The Notch1 signaling pathway contributes to tumorigenesis by influencing differentiation, proliferation and apoptosis. Here, we demonstrate that inhibition of the Notch1 signaling pathway sensitizes glioblastoma cell lines and glioblastoma initiating cells to apoptosis induced by the death ligand TR...

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Detalles Bibliográficos
Autores principales: Fassl, A, Tagscherer, K E, Richter, J, De-Castro Arce, J, Savini, C, Rösl, F, Roth, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632291/
https://www.ncbi.nlm.nih.gov/pubmed/26469969
http://dx.doi.org/10.1038/cddis.2015.261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632291/
https://www.ncbi.nlm.nih.gov/pubmed/26469969
http://dx.doi.org/10.1038/cddis.2015.261

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