Cargando…
Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5
The Notch1 signaling pathway contributes to tumorigenesis by influencing differentiation, proliferation and apoptosis. Here, we demonstrate that inhibition of the Notch1 signaling pathway sensitizes glioblastoma cell lines and glioblastoma initiating cells to apoptosis induced by the death ligand TR...
Autores principales: | Fassl, A, Tagscherer, K E, Richter, J, De-Castro Arce, J, Savini, C, Rösl, F, Roth, W |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632291/ https://www.ncbi.nlm.nih.gov/pubmed/26469969 http://dx.doi.org/10.1038/cddis.2015.261 |
Ejemplares similares
-
TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors
por: Yang, Xi, et al.
Publicado: (2017) -
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients
por: Zhang, Yan, et al.
Publicado: (2011) -
The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations
por: Henken, Florianne E., et al.
Publicado: (2012) -
Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction
por: Hendriks, Djoke, et al.
Publicado: (2016) -
Dasatinib promotes TRAIL‐mediated apoptosis by upregulating CHOP‐dependent death receptor 5 in gastric cancer
por: Wang, Xiaona, et al.
Publicado: (2018)