P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. Although previous studies have reported transcriptional upregulation of nSMase2 in response to daunorubicin, through Sp1 and Sp3 transcription factors, the...

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Detalles Bibliográficos
Autores principales: Shamseddine, A A, Clarke, C J, Carroll, B, Airola, M V, Mohammed, S, Rella, A, Obeid, L M, Hannun, Y A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632297/
https://www.ncbi.nlm.nih.gov/pubmed/26512957
http://dx.doi.org/10.1038/cddis.2015.268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632297/
https://www.ncbi.nlm.nih.gov/pubmed/26512957
http://dx.doi.org/10.1038/cddis.2015.268

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