A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans

Gene-by-environment interactions are thought to underlie the majority of idiopathic cases of neurodegenerative disease. Recently, we reported that an environmental metabolite extracted from Streptomyces venezuelae increases ROS and damages mitochondria, leading to eventual neurodegeneration of C. el...

Descripción completa

Detalles Bibliográficos
Autores principales: Martinez, B A, Kim, H, Ray, A, Caldwell, G A, Caldwell, K A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632299/
https://www.ncbi.nlm.nih.gov/pubmed/26469957
http://dx.doi.org/10.1038/cddis.2015.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632299/
https://www.ncbi.nlm.nih.gov/pubmed/26469957
http://dx.doi.org/10.1038/cddis.2015.270

Ejemplares similares