Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

Lysosomal dysfunction has been implicated both pathologically and genetically in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease (PD). Lysosomal gene deficiencies cause lysosomal storage disorders, many of which involve neurodegeneration. Heterozygous mutat...

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Detalles Bibliográficos
Autores principales: Bae, E-J, Yang, N Y, Lee, C, Kim, S, Lee, H-J, Lee, S-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632307/
https://www.ncbi.nlm.nih.gov/pubmed/26448324
http://dx.doi.org/10.1038/cddis.2015.283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632307/
https://www.ncbi.nlm.nih.gov/pubmed/26448324
http://dx.doi.org/10.1038/cddis.2015.283

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