Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are atten...

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Detalles Bibliográficos
Autores principales: Liu, Xinran, Musser, Derek M., Lee, Cheri A., Yang, Xiaorong, Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632402/
https://www.ncbi.nlm.nih.gov/pubmed/26516899
http://dx.doi.org/10.3390/v7102894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632402/
https://www.ncbi.nlm.nih.gov/pubmed/26516899
http://dx.doi.org/10.3390/v7102894

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