Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated by HH, which promotes its endocytosis and destabi...

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Detalles Bibliográficos
Autores principales: Brigui, Amira, Hofmann, Line, Argüelles, Camilla, Sanial, Matthieu, Holmgren, Robert A., Plessis, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632511/
https://www.ncbi.nlm.nih.gov/pubmed/26446620
http://dx.doi.org/10.1098/rsob.150112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632511/
https://www.ncbi.nlm.nih.gov/pubmed/26446620
http://dx.doi.org/10.1098/rsob.150112

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