Aire controls gene expression in the thymic epithelium with ordered stochasticity

Aire controls immunologic tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire’s specificity, we performed single-cell RNAseq and DNA methylation analysis in Aire-sufficient and...

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Detalles Bibliográficos
Autores principales: Meredith, Matthew, Zemmour, David, Mathis, Diane, Benoist, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632529/
https://www.ncbi.nlm.nih.gov/pubmed/26237550
http://dx.doi.org/10.1038/ni.3247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632529/
https://www.ncbi.nlm.nih.gov/pubmed/26237550
http://dx.doi.org/10.1038/ni.3247

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