Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

The tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying reducing potential for oxidative phosphorylation and anabolic substrates for cell growth, repair and proliferation. As such it thought to be essential for cell proliferation and tissue homeostasis. However, s...

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Detalles Bibliográficos
Autores principales: Lussey-Lepoutre, Charlotte, Hollinshead, Kate E. R., Ludwig, Christian, Menara, Mélanie, Morin, Aurélie, Castro-Vega, Luis-Jaime, Parker, Seth J., Janin, Maxime, Martinelli, Cosimo, Ottolenghi, Chris, Metallo, Christian, Gimenez-Roqueplo, Anne-Paule, Favier, Judith, Tennant, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632646/
https://www.ncbi.nlm.nih.gov/pubmed/26522426
http://dx.doi.org/10.1038/ncomms9784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632646/
https://www.ncbi.nlm.nih.gov/pubmed/26522426
http://dx.doi.org/10.1038/ncomms9784

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