FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity

AIMS: The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog of flavaglines, FL3, efficiently protects mice from the cardiotoxicity of doxorubi...

Descripción completa

Detalles Bibliográficos
Autores principales: Qureshi, Rehana, Yildirim, Onur, Gasser, Adeline, Basmadjian, Christine, Zhao, Qian, Wilmet, Jean-Philippe, Désaubry, Laurent, Nebigil, Canan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633129/
https://www.ncbi.nlm.nih.gov/pubmed/26536361
http://dx.doi.org/10.1371/journal.pone.0141826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633129/
https://www.ncbi.nlm.nih.gov/pubmed/26536361
http://dx.doi.org/10.1371/journal.pone.0141826

Ejemplares similares