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Targeted Expression of Channelrhodopsin-2 to the Axon Initial Segment Alters the Temporal Firing Properties of Retinal Ganglion Cells

The axon initial segment (AIS) is essential for initiating action potentials and maintaining neuronal excitability in axon-bearing neurons in the CNS. There is increasing interest in the targeting of optogenetic tools to subcellular compartments, including the AIS, to gain precise control of neurona...

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Detalles Bibliográficos
Autores principales: Zhang, Zhifei, Feng, Jie, Wu, Chaowen, Lu, Qi, Pan, Zhuo-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633179/
https://www.ncbi.nlm.nih.gov/pubmed/26536117
http://dx.doi.org/10.1371/journal.pone.0142052