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Detecting DNA regulatory motifs by incorporating positional trends in information content

On the basis of the observation that conserved positions in transcription factor binding sites are often clustered together, we propose a simple extension to the model-based motif discovery methods. We assign position-specific prior distributions to the frequency parameters of the model, penalizing...

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Detalles Bibliográficos
Autores principales: Kechris, Katherina J, van Zwet, Erik, Bickel, Peter J, Eisen, Michael B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC463320/
https://www.ncbi.nlm.nih.gov/pubmed/15239835
http://dx.doi.org/10.1186/gb-2004-5-7-r50