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Detecting DNA regulatory motifs by incorporating positional trends in information content
On the basis of the observation that conserved positions in transcription factor binding sites are often clustered together, we propose a simple extension to the model-based motif discovery methods. We assign position-specific prior distributions to the frequency parameters of the model, penalizing...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC463320/ https://www.ncbi.nlm.nih.gov/pubmed/15239835 http://dx.doi.org/10.1186/gb-2004-5-7-r50 |