Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer

With the recent comprehensive mapping of cancer genomes, there is now a need for functional approaches to edit the aberrant epigenetic state of key cancer drivers to reprogram the epi-pathology of the disease. In this study we utilized a programmable DNA-binding methyltransferase to induce targeted...

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Detalles Bibliográficos
Autores principales: Stolzenburg, S, Beltran, A S, Swift-Scanlan, T, Rivenbark, A G, Rashwan, R, Blancafort, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633433/
https://www.ncbi.nlm.nih.gov/pubmed/25684141
http://dx.doi.org/10.1038/onc.2014.470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633433/
https://www.ncbi.nlm.nih.gov/pubmed/25684141
http://dx.doi.org/10.1038/onc.2014.470

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