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Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer
With the recent comprehensive mapping of cancer genomes, there is now a need for functional approaches to edit the aberrant epigenetic state of key cancer drivers to reprogram the epi-pathology of the disease. In this study we utilized a programmable DNA-binding methyltransferase to induce targeted...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633433/ https://www.ncbi.nlm.nih.gov/pubmed/25684141 http://dx.doi.org/10.1038/onc.2014.470 |