Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling

Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the suppression of osteoblast formation are both involved in the pathophysiology of the bone lesions in MM. The proteasome inhibitor (PI) bortezomib...

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Detalles Bibliográficos
Autores principales: Accardi, Fabrizio, Toscani, Denise, Bolzoni, Marina, Dalla Palma, Benedetta, Aversa, Franco, Giuliani, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633537/
https://www.ncbi.nlm.nih.gov/pubmed/26579531
http://dx.doi.org/10.1155/2015/172458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633537/
https://www.ncbi.nlm.nih.gov/pubmed/26579531
http://dx.doi.org/10.1155/2015/172458

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