Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting

Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient’s demography, tumor characteristics, tumor burden, and treatment on survival trend...

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Autores principales: Bhoo-Pathy, Nirmala, Verkooijen, Helena Marieke, Tan, Ern-Yu, Miao, Hui, Taib, Nur Aishah Mohd, Brand, Judith S., Dent, Rebecca A., See, Mee-Hoong, Subramaniam, ShriDevi, Chan, Patrick, Lee, Soo-Chin, Hartman, Mikael, Yip, Cheng-Har
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633674/
https://www.ncbi.nlm.nih.gov/pubmed/26536962
http://dx.doi.org/10.1038/srep16252
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author Bhoo-Pathy, Nirmala
Verkooijen, Helena Marieke
Tan, Ern-Yu
Miao, Hui
Taib, Nur Aishah Mohd
Brand, Judith S.
Dent, Rebecca A.
See, Mee-Hoong
Subramaniam, ShriDevi
Chan, Patrick
Lee, Soo-Chin
Hartman, Mikael
Yip, Cheng-Har
author_facet Bhoo-Pathy, Nirmala
Verkooijen, Helena Marieke
Tan, Ern-Yu
Miao, Hui
Taib, Nur Aishah Mohd
Brand, Judith S.
Dent, Rebecca A.
See, Mee-Hoong
Subramaniam, ShriDevi
Chan, Patrick
Lee, Soo-Chin
Hartman, Mikael
Yip, Cheng-Har
author_sort Bhoo-Pathy, Nirmala
collection PubMed
description Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient’s demography, tumor characteristics, tumor burden, and treatment on survival trend were examined. Patients with de novo metastatic breast cancer from three hospitals in Malaysia and Singapore (N = 856) were grouped by year of diagnosis: 1996–2000, 2001–2005 and 2006–2010. Step-wise multivariable Poisson regression was used to estimate the contribution of above-mentioned factors on the survival trend. Proportions of patients presenting with metastatic breast cancer were 10% in 1996–2000, 7% in 2001–2005, and 9% in 2006–2010. Patients in 2006–2010 were significantly older, appeared to have higher disease burden, and received more chemotherapy, endocrine therapy, and surgery of primary tumor. The three-year relative survival in the above periods were 20·6% (95% CI: 13·9%–28·2%), 28·8% (95% CI: 23·4%–34·2%), and 33·6% (95% CI: 28·8%–38·5%), respectively. Adjustment for treatment considerably attenuated the relative excess risk of mortality in recent years, compared to other factors. Substantial improvements in survival were observed in patients with de novo metastatic breast cancer in this study.
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spelling pubmed-46336742015-11-05 Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting Bhoo-Pathy, Nirmala Verkooijen, Helena Marieke Tan, Ern-Yu Miao, Hui Taib, Nur Aishah Mohd Brand, Judith S. Dent, Rebecca A. See, Mee-Hoong Subramaniam, ShriDevi Chan, Patrick Lee, Soo-Chin Hartman, Mikael Yip, Cheng-Har Sci Rep Article Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient’s demography, tumor characteristics, tumor burden, and treatment on survival trend were examined. Patients with de novo metastatic breast cancer from three hospitals in Malaysia and Singapore (N = 856) were grouped by year of diagnosis: 1996–2000, 2001–2005 and 2006–2010. Step-wise multivariable Poisson regression was used to estimate the contribution of above-mentioned factors on the survival trend. Proportions of patients presenting with metastatic breast cancer were 10% in 1996–2000, 7% in 2001–2005, and 9% in 2006–2010. Patients in 2006–2010 were significantly older, appeared to have higher disease burden, and received more chemotherapy, endocrine therapy, and surgery of primary tumor. The three-year relative survival in the above periods were 20·6% (95% CI: 13·9%–28·2%), 28·8% (95% CI: 23·4%–34·2%), and 33·6% (95% CI: 28·8%–38·5%), respectively. Adjustment for treatment considerably attenuated the relative excess risk of mortality in recent years, compared to other factors. Substantial improvements in survival were observed in patients with de novo metastatic breast cancer in this study. Nature Publishing Group 2015-11-05 /pmc/articles/PMC4633674/ /pubmed/26536962 http://dx.doi.org/10.1038/srep16252 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bhoo-Pathy, Nirmala
Verkooijen, Helena Marieke
Tan, Ern-Yu
Miao, Hui
Taib, Nur Aishah Mohd
Brand, Judith S.
Dent, Rebecca A.
See, Mee-Hoong
Subramaniam, ShriDevi
Chan, Patrick
Lee, Soo-Chin
Hartman, Mikael
Yip, Cheng-Har
Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title_full Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title_fullStr Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title_full_unstemmed Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title_short Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting
title_sort trends in presentation, management and survival of patients with de novo metastatic breast cancer in a southeast asian setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633674/
https://www.ncbi.nlm.nih.gov/pubmed/26536962
http://dx.doi.org/10.1038/srep16252
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