An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

Acute myeloid leukaemia (AML) is characterized by subpopulations of leukaemia stem cells (LSCs) that are defined by their ability to engraft in immunodeficient mice. Here we show an LSC DNA methylation signature, derived from xenografts and integration with gene expression that is comprised of 71 ge...

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Detalles Bibliográficos
Autores principales: Jung, Namyoung, Dai, Bo, Gentles, Andrew J., Majeti, Ravindra, Feinberg, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633733/
https://www.ncbi.nlm.nih.gov/pubmed/26444494
http://dx.doi.org/10.1038/ncomms9489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633733/
https://www.ncbi.nlm.nih.gov/pubmed/26444494
http://dx.doi.org/10.1038/ncomms9489

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